Analysis of woodchuck hepatitis virus dynamics in the woodchuck-WHV infection model during acute versus chronic infection, before and after antiviral treatment

Authors

  • Md Deen Islam University of Calgary, Cumming School of Medicine
  • DP Whiteside University of Calgary, Faculty of Veterinary Medicine
  • JL Rothenburger University of Calgary, Faculty of Veterinary Medicine
  • TI Michalak Memorial University of Newfoundland, Faculty of Medicine
  • S D'Souza University of Calgary, Cumming School of Medicine
  • T Wilayat University of Calgary, Cumming School of Medicine
  • A Chen University of Calgary, Cumming School of Medicine
  • F van der Meer University of Calgary, Faculty of Veterinary Medicine
  • G van Marle University of Calgary, Cumming School of Medicine
  • CN Jenne University of Calgary, Cumming School of Medicine
  • CS Coffin University of Calgary, Cumming School of Medicine

DOI:

https://doi.org/10.55016/pbgrc.v1i1.81408

Abstract

The antiviral effects of Entecavir (ETV) against woodchuck hepatitis virus (WHV) and human hepatitis B virus (HBV) are well established. However, the dynamics of hepadnaviral diversity during disease progression and treatment are not well characterized. We aim to infect woodchucks with WHV followed by serial collection of blood and liver biopsy to assess pathogenesis and hepadnaviral quasispecies with or without ETV treatment. This study will inform the understanding of hepadnaviral reactivation risks after stopping ETV.

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Published

2025-04-29

How to Cite

Deen Islam, M., Whiteside, D., Rothenburger, J., Michalak, T., D'Souza, S., Wilayat, T., … Coffin, C. (2025). Analysis of woodchuck hepatitis virus dynamics in the woodchuck-WHV infection model during acute versus chronic infection, before and after antiviral treatment. Peer Beyond Graduate Research Conference, 1(1), 40–41. https://doi.org/10.55016/pbgrc.v1i1.81408

Issue

Vol. 1 No. 1 (2025): Peer Beyond Graduate Research Conference

Section

Articles